Many first-time donors come to their donation with a fear of needles, but most find that the donation process is easy and relatively painless. If you want to donate but the fear of needles or blood is holding you back, focus on the lives you may be helping to save by making your donation. By giving a single pint of blood, you may help have as many as three lives. You will feel a slight pinch, and that is over in seconds. But the difference you make may last a lifetime.