LOPSIDED. The unbeaten Buffalo Bills, soon to return two key defensive players to the practice field after suspension, host the winless New Orleans Saints on Sunday afternoon.

The Bills are favored by a whopping 16.5 points to send the rabid Highmark Stadium hopeful home happy yet again.

The Bills have won 13 straight regular season games at home and the Saints will become number 14.

Expect Josh Allen and company to dominate from the opening whistle after a 10-day rest.

FREDDIE sees it this way:

BILLS 41, Saints 28

HOME teams are capitalized. Teams picked to win the game are listed first, followed by the expected margin of victory. The official Las Vegas odds are in parentheses.

COLLEGES

Friday

Florida State +10 over VIRGINIA (+6.5)

Saturday

Notre Dame +6 over ARKANSAS (+3.5)

NAVY +11 over Rice (+14.5)

UConn +7 over BUFFALO (+3.5)

Indiana +13 over IOWA (+7.5)

TEXAS A&M +3 over Auburn (+6.5)

Ohio State +10 over WASHINGTON (+8.5)

GEORGIA +9 over Alabama (+3.5)

Oregon +7 over PENN STATE (+3.5)

BYU +12 over COLORADO (+6.5)

WEEK: 8-2 (.800). Vs. line 2-8 (.200).

YEAR: 25-5 (.833). Vs. line 11-19 (.367).

PROS

Thursday

ARIZONA +3 over Seattle (-1.5)

Sunday in Dublin

Pittsburgh +6 over Minnesota (-2.5)

Sunday

BUFFALO +13 over New Orleans (+16.5)

HOUSTON +6 over Tennessee (+7.5)

DETROIT +3 over Cleveland (+8.5)

Washington +4 over ATLANTA (+1.5)

Philadelphia +9 over TAMPA BAY (+3.5)

NEW ENGLAND +3 over Carolina (+5.5)

LA Chargers +8 over NY GIANTS (+6.5)

SAN FRANCISCO +3 over Jacksonville (+2.5)

LA RAMS +5 over Indianapolis (+3.5)

LAS VEGAS +3 over Chicago (+1.5)

Baltimore +6 over KANSAS CITY (+2.5)

Green Bay +3 over DALLAS (+6.5)

Monday

MIAMI +7 over NY Jets (+2.5)

DENVER +10 over Cincinnati (+7.5)

WEEK: 12-4 (.750). Vs. line 10-6 (.625).

YEAR: 37-11 (.771). Vs. line 25-23 (.521).